This claim was loosely supported by a 2020 observational study published in JAMA Psychiatry which found a correlation between higher “acetaminophen buffer” and increased odds of autism spectrum disorder (ASD). However, this studies methodology has later been put under scrutiny, with experts emphasising that as an observational study, it cannot prove causation.
In response, numerous professionals have publicly challenged President Trumps claims. Monique Botha, Associate Professor of Social and Developmental Psychology at Durham University stated, “There is no robust evidence or convincing studies to suggest any causal relationship, and any conclusions being drawn to the contrary are often motivated, under-evidenced and unsupported by the most robust methods”.
In its September 2025 Safety Roundup, the NHS and MHRA continue to advise health care professionals that pregnant women should follow existing NHS guidance. The update emphasises that “recent existing studies do not show a casual association between paracetamol use during pregnancy and autism” and warns that “untreated pain and fever can pose risks to the unborn baby, so it is important that patients continue to manage these symptoms with the recommended treatment". The Department of Health and Social Care has reinforced this message, highlighting the real risks associated with leaving maternal pain and fever untreated.
The MHRA also advises against swapping to alternatives such as ibuprofen, noting that NSAIDs are generally not recommended in late pregnancy. Acetaminophen remains one of the safest pain relief options for expectant mothers. On 24 September, the World Health Organization reaffirmed its stance, stating that despite extensive research over the past decade - including large scale studies - no consistent link has been established between Acetaminophen use during pregnancy and autism.
Current research indicates autism is influenced by both genetic factors - such as Fragile X syndrome - and environmental ones like advanced paternal age or birth complications. A Meta-analysis of twin studies estimates that 60-90% of autism risk is genetic. However, rising autism rates are attributed not to increased causation but to greater awareness, broader diagnostic criteria, and improved screening tools enabling earlier and more frequent detection. This makes it reasonable to conclude that President Trumps claims are unfounded and echo his previous contentious statements regarding therapeutic interventions.